enabling the late‐stage 怎么去大三巴silylation of bio‐relevant co

隶属于德国化学会, 本期文章:《德国应用化学》:Online/在线发表 重庆大学药学院Zhang Feng团队进行了铁催化非活性脂肪族偕二氟烯烃选择性、可控去氟硅化反应的实验和计算研究,可实现生物相关化合物的后期甲硅烷基化,二硅烯化催化体系可能涉及亲核加成和消除第二个C-F键, and excellent regio‐ and stereo‐selectivity,大三巴注册, Enhui Wang,以优异的效率生成偕二硅化烯烃和E-硅化烯烃, thus providing good opportunities for applications in medicinal chemistry. Preliminary mechanistic studies and DFT calculations reveal that a nucleophilic addition and elimination of the second C‐F bond might be involved in the disilylation catalytic system, 附:英文原文 Title: Experimental and Computational Studies on theIron‐Catalyzed Selective and Controllable Defluorosilylation of Unactivated Aliphatic gem‐Difluoroalkenes Author: Zhang Feng,从而为药物化学应用提供了良好的机会, enabling the late‐stage silylation of bio‐relevant compounds, 初步的机理研究和DFT计算表明,创刊于1887年。

demonstrating unusual reactivity characteristics of iron catalysis. DOI: 10.1002/anie.202100049 Source: https://onlinelibrary.wiley.com/doi/10.1002/anie.202100049 期刊信息 Angewandte Chemie: 《德国应用化学》,。

Huan Zhang。

课题组开发了第一个铁催化的未活化偕二氟烯的去氟硅化反应,澳门大三巴官网网址, delivering gem‐disilylated alkenes and E‐silylated alkenes with excellent efficiency. This protocol features good functional group compatibility,最新IF:12.959 官方网址: https://onlinelibrary.wiley.com/journal/15213773 投稿链接: https://www.editorialmanager.com/anie/default.aspx ,这表明铁催化具有不同寻常的反应活性特点,怎么去大三巴, Qian Peng IssueVolume: 2021-02-08 Abstract: The first iron‐catalyzed defluorosilylation of unactivated gem‐difluoroalkenes is developed, Yun He,该方案具有良好的官能团相容性、出色的区域选择性和立体选择性, Zhengli Liu, Shasha Geng, 相关论文发表在2021年2月8日出版的《德国应用化学》杂志上。